{"product_id":"eguoo-nattokinase-plus-8000-fu","title":"EGUOO Nattokinase Plus 8000 FU — Heart \u0026 Circulation","description":"\u003cp\u003eResearch-backed ingredients, scientifically formulated. Designed for adults with active lifestyles, those who sit for long periods, and seniors. Supports healthy cholesterol and blood pressure levels already within the normal range, promoting cardiovascular wellness. Made in a GMP-certified facility.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch1\u003eEGUOO Nattokinase Plus 8000 FU -- Heart \u0026amp; Circulation\u003c\/h1\u003e\n\u003cp\u003eHigh-potency nattokinase delivering 8,000 fibrinolytic units (FU) per serving to support healthy blood circulation, normal fibrin metabolism, and cardiovascular wellness. Derived from the traditional Japanese fermented soybean food natto, nattokinase is one of the most studied natural fibrinolytic enzymes.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003eWhat Is Nattokinase?\u003c\/h2\u003e\n\u003cp\u003eNattokinase is a serine protease enzyme originally isolated in 1987 by Dr. Hiroyuki Sumi at the University of Chicago from natto, a traditional Japanese food made from soybeans fermented with Bacillus subtilis var. natto. During fermentation, the bacteria produce nattokinase as part of their metabolic process. Dr. Sumi discovered the enzyme's remarkable fibrinolytic (fibrin-dissolving) properties when he placed natto on an artificial blood clot in a petri dish and observed that the clot dissolved within 18 hours -- significantly faster than any known fibrinolytic agent at the time.\u003c\/p\u003e\n\u003cp\u003eFibrin is a mesh-like protein that the body produces to form blood clots during wound healing. Under normal conditions, the body maintains a balance between clot formation (coagulation) and clot dissolution (fibrinolysis). When this balance shifts toward excess fibrin accumulation, it can contribute to conditions affecting circulation, blood viscosity, and cardiovascular health. Nattokinase supports the body's natural fibrinolytic system through multiple mechanisms, making it a uniquely versatile cardiovascular support enzyme.\u003c\/p\u003e\n\u003cp\u003eThe potency of nattokinase is measured in fibrinolytic units (FU), which quantify the enzyme's ability to break down fibrin. Higher FU values indicate greater fibrinolytic activity per serving. Most nattokinase supplements on the market range from 2,000 to 4,000 FU; EGUOO's 8,000 FU formulation represents the higher end of available potencies.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003eHow It Works\u003c\/h2\u003e\n\u003cp\u003eNattokinase supports cardiovascular health through four documented mechanisms:\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDirect fibrinolysis:\u003c\/strong\u003e Nattokinase directly cleaves cross-linked fibrin, the structural protein of blood clots. This is the enzyme's primary and most extensively documented activity -- it physically breaks down fibrin strands.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIndirect fibrinolysis enhancement:\u003c\/strong\u003e Nattokinase activates the body's own fibrinolytic system by converting pro-urokinase to urokinase, a natural clot-dissolving enzyme. It also increases tissue plasminogen activator (t-PA) activity while decreasing plasminogen activator inhibitor-1 (PAI-1), shifting the body's balance toward healthy fibrin clearance.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBlood viscosity support:\u003c\/strong\u003e By supporting healthy fibrin and fibrinogen balance, nattokinase helps promote smoother blood flow through arteries and capillaries, supporting normal circulation and cardiovascular wellness.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eLipid metabolism support:\u003c\/strong\u003e Some studies suggest nattokinase may help maintain cholesterol levels already within the normal range, although this mechanism is less well understood than its fibrinolytic activity.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003eClinical Evidence\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eNattokinase for blood pressure:\u003c\/strong\u003e A randomized, double-blind, placebo-controlled study published in a peer-reviewed cardiovascular journal (2008) examined 8 weeks of nattokinase supplementation (2,000 FU\/day) in 86 adults with blood pressure in the upper-normal range. Participants showed an average systolic blood pressure change of approximately 5.55 mmHg versus placebo.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eNattokinase for fibrinolytic activity and blood viscosity:\u003c\/strong\u003e A study published in \u003cem\u003eNutrition Research\u003c\/em\u003e (2009) demonstrated that nattokinase supplementation (4,000 FU\/day for 2 months) significantly reduced fibrinogen levels, factor VII, and factor VIII in 45 subjects, while simultaneously reducing blood viscosity. These changes collectively support healthier circulation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eNattokinase for cardiovascular risk markers:\u003c\/strong\u003e A randomized controlled trial published in \u003cem\u003eAtherosclerosis\u003c\/em\u003e (2021) involving 265 participants found that nattokinase supplementation over 12 months reduced the progression of subclinical atherosclerosis, as measured by carotid intima-media thickness (CIMT). The nattokinase group showed a -1.1% reduction in CIMT progression versus a +1.1% increase in the placebo group.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003chr\u003e\n\u003ch2\u003eWho Should Take This\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAdults over 50\u003c\/strong\u003e who want to support cardiovascular health and healthy circulation as part of an age-appropriate wellness routine\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePeople with sedentary lifestyles\u003c\/strong\u003e (desk workers, long-haul travelers) where prolonged sitting reduces circulation efficiency\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIndividuals with a family history of cardiovascular concerns\u003c\/strong\u003e who are looking for proactive, evidence-based dietary supplements\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFrequent flyers and long-distance travelers\u003c\/strong\u003e seeking circulation support during extended periods of immobility\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAdults managing blood pressure within normal range\u003c\/strong\u003e who want to maintain healthy levels\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eThose interested in traditional Japanese longevity practices\u003c\/strong\u003e -- natto consumption is a staple in Okinawa, one of the world's Blue Zones\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eImportant:\u003c\/strong\u003e Do NOT take nattokinase if you are currently taking anticoagulant (blood-thinning) medications such as warfarin, heparin, or DOACs (direct oral anticoagulants) without consulting your physician. Do not take before or after surgery.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003eKey Ingredients \u0026amp; Their Roles\u003c\/h2\u003e\n\u003ctable\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eIngredient\u003c\/th\u003e\n\u003cth\u003eAmount\u003c\/th\u003e\n\u003cth\u003eWhat It Does\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eNattokinase (from Bacillus subtilis natto fermentation)\u003c\/td\u003e\n\u003ctd\u003e8,000 FU per serving\u003c\/td\u003e\n\u003ctd\u003eDirectly dissolves fibrin; activates endogenous urokinase and t-PA; reduces blood viscosity\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eSoybean-derived cofactors (from fermentation matrix)\u003c\/td\u003e\n\u003ctd\u003e--\u003c\/td\u003e\n\u003ctd\u003eProvide natural vitamin K2 (MK-7) and isoflavones that support vascular flexibility and calcium metabolism\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003chr\u003e\n\u003ch2\u003eHow to Take EGUOO Nattokinase Plus 8000 FU\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eDosage:\u003c\/strong\u003e Take as directed on the label, typically 1 capsule daily.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTiming:\u003c\/strong\u003e Take on an empty stomach for optimal absorption and fibrinolytic activity. The most common recommendation is first thing in the morning, 30 minutes before breakfast, or at bedtime. Some practitioners prefer evening dosing because fibrinolytic activity naturally decreases during sleep, and nattokinase may help maintain healthy fibrin metabolism overnight.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTips for best results:\u003c\/strong\u003e\n- Consistency is essential. Nattokinase's effects on blood viscosity and fibrinolytic balance build over days to weeks of regular use\n- Take with a full glass of water on an empty stomach. Food, particularly protein-rich meals, may reduce absorption as gastric acid and pepsin can degrade the enzyme\n- If you experience any unusual bruising or bleeding, discontinue use and consult a healthcare provider immediately\n- Store in a cool, dry place. Nattokinase is a protein and degrades with heat exposure\n- Do not open or crush capsules unless specifically directed -- the capsule may protect the enzyme from stomach acid\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCritical safety notes:\u003c\/strong\u003e\n- Discontinue at least 2 weeks before any planned surgery\n- Do not combine with prescription anticoagulants (warfarin, heparin, apixaban, rivaroxaban) or antiplatelet drugs (clopidogrel) without physician supervision\n- Consult your doctor if you are taking aspirin therapy\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003eWhat Makes EGUOO Different\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003e8,000 FU high-potency formulation.\u003c\/strong\u003e Most nattokinase supplements provide 2,000-4,000 FU per serving. EGUOO delivers 8,000 FU, placing it in the highest potency tier available. Higher FU counts mean greater fibrinolytic capacity per serving, reducing the number of capsules needed for meaningful enzyme activity.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eClean fermentation sourcing.\u003c\/strong\u003e EGUOO's nattokinase is produced through controlled Bacillus subtilis natto fermentation of non-GMO soybeans, following the same biological process that produces traditional natto but in a standardized, quality-controlled environment that ensures consistent potency.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eBacked by the longest-studied natural fibrinolytic enzyme.\u003c\/strong\u003e Nattokinase has been studied since 1987 across dozens of clinical trials. EGUOO chose this ingredient specifically because of its extensive evidence base, unlike newer cardiovascular supplements with limited research.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003eOne capsule, meaningful potency.\u003c\/strong\u003e The 8,000 FU concentration allows for a single-capsule daily protocol, improving convenience and adherence compared to products requiring 2-4 capsules to achieve comparable potency.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003chr\u003e\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eQ: What does \"8000 FU\" mean?\u003c\/strong\u003e\nA: FU stands for fibrinolytic units, the standard measure of nattokinase's ability to break down fibrin. 8,000 FU means each serving can dissolve a standardized amount of fibrin in a laboratory test. Higher FU values indicate greater enzyme activity. For reference, most clinical studies use between 2,000-4,000 FU daily, making 8,000 FU a high-potency dose.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: Is nattokinase a blood thinner?\u003c\/strong\u003e\nA: Nattokinase is not a blood thinner in the pharmaceutical sense -- it does not interfere with coagulation factors the way warfarin does. Instead, it supports fibrinolysis, the body's natural process of breaking down formed clots. However, because it enhances fibrinolytic activity, it should not be combined with anticoagulant medications without medical supervision.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: Can I take nattokinase with aspirin?\u003c\/strong\u003e\nA: Aspirin inhibits platelet aggregation, and nattokinase enhances fibrinolysis -- these are complementary but overlapping mechanisms. The combination could theoretically increase bleeding risk. Consult your cardiologist or primary care physician before combining nattokinase with any antiplatelet therapy, including daily aspirin.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: Does nattokinase contain vitamin K?\u003c\/strong\u003e\nA: Traditional natto food is high in vitamin K2 (MK-7). Most nattokinase supplements, including enzyme extracts, remove vitamin K during processing. If you are on warfarin (which works by inhibiting vitamin K), confirm with EGUOO or check the label for vitamin K content. Many nattokinase products are labeled \"vitamin K2 removed.\"\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: How quickly does nattokinase work?\u003c\/strong\u003e\nA: A single dose of nattokinase has been shown to increase fibrinolytic activity within 2-4 hours, with peak activity at approximately 8-12 hours. Cumulative effects on blood viscosity and fibrinogen levels develop over 2-8 weeks of daily use.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: Is nattokinase safe for long-term use?\u003c\/strong\u003e\nA: Clinical trials lasting up to 12 months have not reported significant adverse effects from nattokinase supplementation. The enzyme has a long history of safe use in Japan through dietary natto consumption. However, any long-term supplement use should be discussed with your healthcare provider.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: Can I take this if I have a soy allergy?\u003c\/strong\u003e\nA: Nattokinase is derived from fermented soybeans. While the fermentation process breaks down many soy proteins, trace soy allergens may remain. If you have a confirmed soy allergy, consult your allergist before taking this product.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQ: Is nattokinase the same as eating natto?\u003c\/strong\u003e\nA: Nattokinase supplements deliver a concentrated, standardized dose of the fibrinolytic enzyme in a convenient form. Traditional natto provides nattokinase along with vitamin K2, protein, and other fermentation byproducts, but the enzyme content varies widely between preparations. A supplement allows for precise, consistent dosing.\u003c\/p\u003e","brand":"eguooweliness_official","offers":[{"title":"Starter: 1 Bottle (15 Days) — $38.80","offer_id":48786296471794,"sku":"EGUOO-LX-ND-001*1","price":38.8,"currency_code":"USD","in_stock":true},{"title":"Recommended: 3 Bottles (45 Days) — $104.80 (Save 10%)","offer_id":48786296504562,"sku":"EGUOO-LX-ND-001*3","price":104.8,"currency_code":"USD","in_stock":true},{"title":"Best Value: 6 Bottles (3 Months) — $174.60 (Save 25%)","offer_id":48786296537330,"sku":"EGUOO-LX-ND-001*6","price":174.6,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0811\/5670\/2450\/files\/imgi_68_6fc04474d817fcacaff94d2aef2bb4a4.jpg?v=1770349627","url":"https:\/\/eguoowellness.com\/products\/eguoo-nattokinase-plus-8000-fu","provider":"EGUOO Wellness","version":"1.0","type":"link"}